Steeve BouraneDiabète athérothrombose Thérapies Réunion Océan Indien (DéTROI) -Inserm U1188 / Université de La Réunion
Since the beginning of my PhD, the main focus of my research is to identify and study neurons and circuits responsible for the genesis and transmission of somatosensory information from the periphery to the brain in normal and pathological condition. I did my PhD (2003-2007) in the laboratory of Pr. Jean Valmier and Dr. Patrick Carroll at the Institute for Neurosciences of Montpellier (Montpellier, France) followed by two years of temporary lecturer and research assistant (ATER) at the University of Montpellier II. From 2010 to 2016, I performed a postdoctoral training with Pr. Martyn Goulding at the Salk Institute (La Jolla, California, USA) and from 2017 to 2019 with Dr. Olivier Meilhac in DéTROI lab / Inserm 1188 – University of Reunion (Reunion, France). In 2019, I have been recruited as a tenured Research Fellow (Chargé de Recherche) at INSERM and I was also the laureate for the ATIP-Avenir program that will allowed me to create and lead a research team working on diabetic neuropathy.
Mon projet ATIP-Avenir
Dissection of somatosensory circuits in diabetic neuropathy
Diabetes mellitus (DM) is one of the most common chronic diseases affecting mankind, having reached epidemic levels. One of the earliest and main complications of type 1 and 2 DM is diabetic neuropathy (DN), a disorder of sensory nerves. Early in the course of DM, patients generally experience abnormal sensory symptoms such as pain, tingling, burning, stinging sensations (paresthesias), pain evoked by innocuous mechanical stimuli (allodynia) and increase sensitivity to noxious stimuli (hyperalgesia), as well as sensory deficits such as numbness. This progressive loss of lower extremity sensation often leads to tissue damage including severe deeply penetrating ulcers that increase the risk of amputation of the toe, foot, or leg. The ATIP-Avenir project aims to better understand how DM affects primary sensory neurons subtypes and dorsal spinal cord circuits that process somatosensory information and how these neurons are involve during the course of the disease. We will use a combinaison of mouse genetic, imaging, electrophysiological and behavioral approaches to better understand the disease mechanisms that operate at the different levels of the somotosensory circuits.