Molecular basis for membrane remodelling and organisation

Chairperson: Ludger JOHANNES
Institut Curie, UMR3666 CNRS – U1143 INSERM, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Phone: +33 (0)1 56 24 63 51
Email: ludger.johannes@curie.fr

Vice-chairperson: Anne-Claude GAVIN
Université de Genève, Centre Medical Universitaire, Rue Michel-Servet 1, 1211 Genève 4, Switzerland
Phone: +41 22 379 50 56
Email: Anne-Claude.Gavin@unige.ch

The selective transport across membranes, often requires that biomolecules are englobed in vesicular or tubular carriers that detach from donor compartments and then fuse with acceptor compartments. The biogenesis of these carriers by bud formation and membrane scission, and their fusion with acceptor membranes are tightly regulated processes for which the membranes must undergo narrow curvature changes. These cannot occur spontaneously, but need to be driven by protein machinery, in interaction with membrane lipids. Protein-lipid assemblies are very dynamic, often involving multiple bond interactions that are individually of low affinity. The field of membrane remodelling and organisation therefore is a fruitful ground of conceptual and methodological innovation. The 2021 ‘Molecular Basis for Membrane Remodelling and Organisation’ Jacques Monod meeting will address new emerging areas that have lately been particularly dynamic: the resolution revolution in cryo-electron microscopy (cryo-EM), which opens unprecedented possibilities for near-atomistic structure determination on model membrane substrates and in cells; the rise of chemical biology as a source for tailor-made tools and ground-breaking concepts in the life sciences; and the integration of membrane biogenesis with metabolism based on ever more performant mass spectroscopy equipment that allows to work with ever smaller quantities of materials. More generally, interdisciplinary has become second to none in the field of membrane remodelling and organisation, and the 2021 meeting will keep on nurturing this spirit. Indeed, also biophysics, computational biology, and systems biology continue to play a key role as a provider of novel conceptual perspectives and methodological innovation, and the proposed program includes a number of physicist speakers whose capacity to engage productively with the membrane biology community is well established. Quantitative live cell imaging in 3D is probably amongst the most prominent examples of successful imbrication between physics and biology.

 

Invited speakers
(provisional titles)

Corinne Albigès-Rizo (Institut pour l'Avancée des Biosciences, La Tronche, France)
Spatial compartmentalization of adhesion molecules and mechanotransduction of signals to the nucleus

Bruno Antonny (IPMC, Valbonne, France)
Dynamics of lipid membranes and coat proteins

Patricia Bassereau (Institut Curie, Paris, France)
Biophysics of membranes and mechanisms of membrane trafficking using synthetic biology approaches

Marie-Cécile Caillaud (ENS de Lyon, Lyon, France)
Lipid signaling during plant cell division and organogenesis

Giovanni D’Angelo (EPFL, Lausanne, Switzerland)
Glycosphingolipids make-up determines cellular identity during development

Arnaud Echard (Institut Pasteur, Paris, France)
Membrane remododeling during the terminal steps of cell division

Chloé Feral (Institute for Research on Cancer and Aging, Nice, France)
Sphingolipid metabolism in the regulation of mechano-sensing by integrins

Katharina Gaus (EMBL Australia, Randwick, Australia)
Superresolution imaging of membrane organization

Cécile Gauthier-Rouvière (CRBM, Montpellier, France)
Endocytic processes in cell-cell and tumor microenvironment remodeling

Anne-Claude Gavin (EMBL, Heidelberg, Germany)
Lipid cooperativity in protein-membrane interactions

Nir Gov (Weizmann Institute of Science, Rehovot, Israel)
Physics of membrane deformation and cytoskeleton

Volker Haucke (FMP, Berlin, Germany)
Molecular mechanisms of endocytosis and endosomal membrane dynamics

Jenny E. Hinshaw (National Institutes of Health, Bethesda, USA)
Structural properties of dynamins in diverse cellular functions

Doris Höglinger (Heidelberg University, Heidelberg, Germany)
Chemical tools and sensors to study lipid-mediated signaling

Jonathon Howard (Yale University, New Haven, USA)
Biochemistry and biophysics of the cytoskeleton

Elina Ikonen (University of Helsinki, Helsinki, Finland)
Imaging methods to study inherited lysosomal lipid storage disorders

Ludger Johannes (Institut Curie, Paris, France)
Acute regulation of glycolipid-lectin (GL-Lect) endocytosis

Anne K. Kenworthy (University of Virginia, Charlottesville, USA)
Structural biology of caveolae

Benoît Kornmann (University of Oxford, Oxford, United Kingdom)
Lipid exchange at membrane contact sites

Yamuna Krishnan (University of Chicago, Chicago, USA)
Quantitative imaging of organellar ions in living systems

Christophe Lamaze (Institut Curie, Paris, France)
Mechanobiology of caveolae

Emmanuel Lemichez (Institut Pasteur, Paris, France)
Interference of toxins with membrane biomechanics during bacterial invasive processes

Harvey T. McMahon (MRC Laboratory of Molecular Biology, Cambridge, United Kingdom)
Endocytic membrane sculpting mechanisms

Guillaume Montagnec (Institut Gustaf Roussy, Paris, France)
Role of clathrin-coated structures in mechanotransduction and cell migration

William Prinz (NIH, Bethesda, USA)
Regulation of shape and lipid composition of membranes to optimize organelle function

Tom A. Rapoport (Harvard Medical School, Boston, USA)
How organelles form and maintain their characteristic shapes

Cristina Risco-Ortiz (National Center for Biotechnology, Madrid, Spain)
Correlative light and electron microscopy to study the assembly and architecture of virus factories

Daniel Röderer (Max Planck Institute of Mol. Physiology, Dortmund, Germany)
Cryo-EM of bacterial and eukaryotic membrane proteins

Petra Schwille (Max-Planck-Institute of Biochemistry, Martinsried, Germany)
Mutual dependence of protein self-organization and membrane remodeling

Ilpo Vattulainen (University of Helsinki, Helsinki, Finland)
Physics, chemistry, computational and medical sciences of membrane systems
 

 

Registration fee (including board and lodging)

• 460 € for PhD students
• 700 € for other participants

 

Application for registration

The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should deposit online before the deadline: https://cjm2-2021.sciencesconf.org/

• their curriculum vitae
• the list of their main publications for the 3 last years
• the abstract of their presentation:

The abstract must respect the following template: TemplateResumeFile

• First line: title
• Second line: list of authors. Presenting author underlined
• Third line: author's addresses
• Fourth line: e-mail of the presenting author

Abstracts should be no longer than an A4 page and preferably be submitted in Times New Roman, font size 10 pts. No figures. ".docx" file format.

After the deadline, the organizers will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay wil