Genome instability: when RNA meets chromatin

Roscoff (Bretagne), France,September 16-20, 2019

Deadline for application : May 28, 2019

Chairperson: Andrés Aguilera

CABIMER-Universidad de Sevilla, Av. Américo Vespucio 24, 41092 Sevilla, Spain 
Phone: +34 954 468 372

Vice-chairperson: Gaelle Legube

CBI (Centre de Biologie Integrative) LBCMCP-CNRS UMR5088, University of Toulouse, 118 route de Narbonne, 31062 Toulouse, Cedex 09, France
Phone: +33 (0)5 61 55 74 97

Research in the last two decades has revealed a surprising interplay between the DNA Damage Response (DDR) and RNA biology. It has been shown that transcription and RNA processing can interfere with DNA replication, thus becoming a serious potential threat to genome stability. Reciprocally, DNA lesions able to interfere with replication and transcription globally impact on different steps of RNA metabolism including RNA splicing and stability. In addition, recent observations suggest a potential important role of non-coding RNAs in the DDR. Finally, RNAs also act as key players regulating histones modifications, chromatin and chromosome organization that further influence all DNA metabolic processes from replication to repair. Altogether this recent research puts RNA as a key molecule in the whole network of DDR with both a potential positive and negative role in genome integrity, and DDR has emerged at the center of this complex interplay between DNA synthesis, transcription, RNA processing and chromatin, with major consequences for genomic instability. The aim of this Jacques Monod conference is to bring together experts from these different rapidly-changing fields in order to discuss the most recent results on these novel and important issues. In particular, we expect to discuss the following topics: a) Transcription and RNA as threats; b) Replication conflicts; c) Nuclear compartments and the DDR; d) DSB repair; e) The RNA in the DDR; e) Chromatin modifications in genome integrity, and f) Mechanisms of telomere integrity.

Invited speakers
(provisional titles)

Andrés Aguilera (Chair) (CABIMER-Universidad de Sevilla, Sevilla, Spain)
RNA and chromatin in transcription-replication conflicts

Gaelle Legube (Vice-chair) (Université de Toulouse, Toulouse, France)
Chromatin and chromosome dynamics in DNA Double Strand Break repair

Fabrizio d’Adda di Fagagna (FIRC Institute of Molecular Oncology, Milan, Italy
DNA breaks trigger transcription

Genevieve Almouzni (Curie Institute, Paris, France)
Histones variants and genome stability - links with RNA

Haiko van Attikum (Leiden University Medical Center, Leiden, The Netherlands)
Regulation and dynamics of DNA repair in a chromatin context

Aura Carreira (Curie Institute, Paris, France)
Interplay between homologous recombination and RNA metabolism, a case from the tumor suppressor BRCA2

Karlene Cimprich (Stanford University, Stanford, USA)
Mechanisms for RNA-Mediated Genome Instability

Priscilla Cooper (Lawrence Berkeley Laboratory, Berkeley, USA)
XPG functions with BRCA2 in genome stability and R-loop modulation

Frederic Chedin (Genome Center, Davis, USA)
Understanding R-loop formation from modeling to single molecule profiling

Michelle Debatisse (Curie Institute, Paris, France)
ATR, a major regulator of the replication dynamics

Jessica Downs (The Institute of Cancer Research, London, United Kingdom)
The SWI/SNF chromatin remodeling complex maintains genome stability through multiple mechanisms

Daniel Durocher (Lunenfeld-Tanenbaum Research Institute, Toronto, Canada)
Charting the genetic architecture of the DNA damage response

Emmanuelle Fabre (Hôpital St. Louis, Paris, France)
Genome stability: what role for chromatin dynamics?

Marco Foiani (IFOM-IEO Campus, Milan, Italy)
Coordinating transcription and replication

Vincent Geli (Marseille Cancer Research Center, Marseille, France)
Role of the Nuclear Pore Complex in the repair of damaged telomeres in S. cerevisiae

Monica Gullerova (University of Oxford, Oxford, United Kingdom)
RNA dependent DNA damage response

Thanos Halazonetis (University of Geneva, Geneva, Switzerland
DNA replication stress in cancer

Pablo Huertas (CABIMER, Universidad de Sevilla, Sevilla, Spain)
A novel connection between DNA repair and RNA editing

Titia de Lange (Rockefeller University, New York, USA)
Telomeric Replication Stress

Brian Luke (Institute of Molecular Biology (IMB), Mainz, Germany)
The dynamic regulation of RNase H enzymes at telomeres

Marcel Mechali (Institute of Human Genetics, Montpellier, France)
DNA replication origins, licensing reaction, and genome instability

Houra Merrikh (University of Washington, Seattle, USA)
The intimate relationship between replication and transcription

Eugene Nudler (Howard Hughes Medical Institute, New York, USA)
New principles of transcription-coupled DNA repair in bacteria

Philippe Pasero (Université de Montpellier, Montpellier, France)
Transcription-Replication conflicts in yeast and human cells

Craig Peterson (University of Massachusetts Medical School, Worcester, USA)
Chromatin dynamics and transcriptional homeostasis

Sophie Polo (Université Paris Diderot, Paris, France)
Epigenome maintenance in response to DNA damage

Evi Soutoglou (Université de Strasbourg; Strasbourg, France)
DNA repair in different heterochromatin structures

Manuel Stucki (University of Zurich, Schlieren, Switzerland)
TCOF1/Treacle controls the nucleolar response to DNA double-strand breaks

Tereisa Texeira (Sorbonne Universités, Paris, France)
How telomeres determine replicative potential

Wim Vermeulen (Erasmus University Medical Center, Rotterdam, The Netherlands)
Transactions at transcription-blocking DNA lesions

Deadline for application : May 28, 2019

Registration fee (including board and lodging)

500 € for PhD students
700 € for other participants

Application for registration
The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should deposit online before the deadline:

- their curriculum vitae
- the list of their main publications for the 3 last years
- the abstract of their presentation:

The abstract must respect the following template: TemplateResumeFile
- First line: title
- Second line: list of authors. Presenting author underlined
- Third line: author's addresses
- Fourth line: e-mail of the presenting author
Abstracts should be no longer than an A4 page and preferably be submitted in Times New Roman, font size 10 pts. No figures. ".docx" file format.

After the deadline, the organizers will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.